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NNT (gene)
NAD(P) transhydrogenase, mitochondrial is an enzyme that in humans is encoded by the ''NNT'' gene on chromosome 5.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23530 )〕
The NNT gene contains 26 exons and encodes a transhydrogenase protein that is ~109 kDa in molecular weight and is involved in antioxidant defense in the mitochondria. Two alternatively spliced variants, encoding the same protein, have been found for this gene.〔
== Structure ==
Transhydrogenases including NNT can exist in an ‘open’ conformation, where substrates can bind and products can dissociate, in which the dihydronicotinamide and nicotinamide rings are held apart to block hydride transfer. It can exist in an ‘occluded’ conformation, where the substrates are moved into apposition to permit redox chemistry.〔 The protein comprises three subunits (dI, dII and dIII), with the dII component spanning the inner mitochondrial membrane. X-ray crystallography structure of the protein shows that proton pumping is probably coupled to changes in the binding affinities of dIII for NADP(+) and NADPH. The first betaalphabetaalphabeta motif of dIII contains a Gly-X-Gly-X-X-Ala/Val fingerprint, whereas the nicotinamide ring of NADP(+) is located on a ridge where it can interact with NADH on the dI subunit.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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